Thursday, August 7, 2008

The latest on PPMD research

The July 31 issue of Neuron reported some promising news for PPMD treatment. I'll do my best to put the researcher's findings in lay terms.

The researchers found (in mice) that when the brain has dysregulated levels of GABA receptors, mice showed more signs of anxiety and depression after birth and had a higher pup mortality rate. When the mice were treated with Gaboxadol, a drug originally designed to treat sleep disorders, the GABA-recptor-affected mice had fewer PPMD-like symptoms, as with those mice with well-regulated GABA receptors.

The researchers, thus, believe that (in humans) post-partum mood disorders and potentially premenstrual syndrome and premenstrual dysphoric disorder may be caused by impaired trafficking of GABA receptors, and not by fluctuations in hormonal levels, as previously believed.

Let's hope this latest research brings us one step closer to finding a successful treatment for PPMDs and other health concerns.

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